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- drugbank_resource:DB00344_DB00472 type drugbank_vocabulary:Drug-Drug-Interaction assertion.
- drugbank_resource:DB00344_DB00472 label "DDI between Protriptyline and Fluoxetine - The SSRI, fluoxetine, may increase the serum concentration of the tricyclic antidepressant, protriptyline, by decreasing its metabolism. Additive modulation of serotonin activity also increases the risk of serotonin syndrome. Monitor for development of serotonin syndrome during concomitant therapy. Monitor for changes in the therapeutic and adverse effects of protriptyline if fluoxetine is initiated, discontinued or dose changed. [drugbank_resource:DB00344_DB00472]" assertion.
- drugbank_resource:DB00344_DB00472 identifier "drugbank_resource:DB00344_DB00472" assertion.
- drugbank_resource:DB00344_DB00472 title "DDI between Protriptyline and Fluoxetine - The SSRI, fluoxetine, may increase the serum concentration of the tricyclic antidepressant, protriptyline, by decreasing its metabolism. Additive modulation of serotonin activity also increases the risk of serotonin syndrome. Monitor for development of serotonin syndrome during concomitant therapy. Monitor for changes in the therapeutic and adverse effects of protriptyline if fluoxetine is initiated, discontinued or dose changed." assertion.