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- drugbank_resource:DB00382_DB00477 type drugbank_vocabulary:Drug-Drug-Interaction assertion.
- drugbank_resource:DB00382_DB00477 label "DDI between Tacrine and Chlorpromazine - The therapeutic effects of the central acetylcholinesterase inhibitor (AChEI), Tacrine, and/or the anticholinergic/antipsychotic, Chlorpromazine, may be reduced due to antagonism. This interaction may be beneficial when the anticholinergic action is a side effect. AChEIs may also augment the central neurotoxic effect of antipsychotics. Monitor for extrapyramidal symptoms and decreased efficacy of both agents. [drugbank_resource:DB00382_DB00477]" assertion.
- drugbank_resource:DB00382_DB00477 identifier "drugbank_resource:DB00382_DB00477" assertion.
- drugbank_resource:DB00382_DB00477 title "DDI between Tacrine and Chlorpromazine - The therapeutic effects of the central acetylcholinesterase inhibitor (AChEI), Tacrine, and/or the anticholinergic/antipsychotic, Chlorpromazine, may be reduced due to antagonism. This interaction may be beneficial when the anticholinergic action is a side effect. AChEIs may also augment the central neurotoxic effect of antipsychotics. Monitor for extrapyramidal symptoms and decreased efficacy of both agents." assertion.