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- NP299683.RAT-BA0mpJScaynUHC0__RgesolQkdnH63UYwJKi8tx64130_assertion type Assertion NP299683.RAT-BA0mpJScaynUHC0__RgesolQkdnH63UYwJKi8tx64130_head.
- NP299683.RAT-BA0mpJScaynUHC0__RgesolQkdnH63UYwJKi8tx64130_assertion description "[The specific blockade or siRNA-mediated suppression of SFK/FAK, JAK2/STAT5, PI3-kinase/PDK1/Akt, Rac/PAK or Ras regulatory circuits revealed that (1) the PI3-kinase/Akt pathway is required for activation of the MAPK/ERK signaling cascade upon PRL stimulation; (2) PI3-kinase-mediated activation of the c-Raf-MEK1/2-ERK1/2 cascade occurs independent of signaling dowstream of STATs, Akt and PKC, but requires JAK2, SFKs and FAK activities; (3) activated PRL-R mainly utilizes the PI3-kinase-dependent Rac/PAK pathway rather than the canonical Shc/Grb2/SOS/Ras route to initiate and sustain ERK1/2 signaling.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP299683.RAT-BA0mpJScaynUHC0__RgesolQkdnH63UYwJKi8tx64130_provenance.
- NP299683.RAT-BA0mpJScaynUHC0__RgesolQkdnH63UYwJKi8tx64130_assertion evidence source_evidence_literature NP299683.RAT-BA0mpJScaynUHC0__RgesolQkdnH63UYwJKi8tx64130_provenance.
- NP299683.RAT-BA0mpJScaynUHC0__RgesolQkdnH63UYwJKi8tx64130_assertion SIO_000772 21726627 NP299683.RAT-BA0mpJScaynUHC0__RgesolQkdnH63UYwJKi8tx64130_provenance.
- NP299683.RAT-BA0mpJScaynUHC0__RgesolQkdnH63UYwJKi8tx64130_assertion wasDerivedFrom befree-20140225 NP299683.RAT-BA0mpJScaynUHC0__RgesolQkdnH63UYwJKi8tx64130_provenance.
- NP299683.RAT-BA0mpJScaynUHC0__RgesolQkdnH63UYwJKi8tx64130_assertion wasGeneratedBy ECO_0000203 NP299683.RAT-BA0mpJScaynUHC0__RgesolQkdnH63UYwJKi8tx64130_provenance.