Matches in Nanopublications for { <http://rdf.disgenet.org/nanopublications.trig#NP423764.RA8NRfMl3pTf4kFHQeeoZI2RHA95sVzqM2kBbZMSv9ga8130_assertion> ?p ?o ?g. }
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- NP423764.RA8NRfMl3pTf4kFHQeeoZI2RHA95sVzqM2kBbZMSv9ga8130_assertion type Assertion NP423764.RA8NRfMl3pTf4kFHQeeoZI2RHA95sVzqM2kBbZMSv9ga8130_head.
- NP423764.RA8NRfMl3pTf4kFHQeeoZI2RHA95sVzqM2kBbZMSv9ga8130_assertion description "[The specific blockade or siRNA-mediated suppression of SFK/FAK, JAK2/STAT5, PI3-kinase/PDK1/Akt, Rac/PAK or Ras regulatory circuits revealed that (1) the PI3-kinase/Akt pathway is required for activation of the MAPK/ERK signaling cascade upon PRL stimulation; (2) PI3-kinase-mediated activation of the c-Raf-MEK1/2-ERK1/2 cascade occurs independent of signaling dowstream of STATs, Akt and PKC, but requires JAK2, SFKs and FAK activities; (3) activated PRL-R mainly utilizes the PI3-kinase-dependent Rac/PAK pathway rather than the canonical Shc/Grb2/SOS/Ras route to initiate and sustain ERK1/2 signaling.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP423764.RA8NRfMl3pTf4kFHQeeoZI2RHA95sVzqM2kBbZMSv9ga8130_provenance.
- NP423764.RA8NRfMl3pTf4kFHQeeoZI2RHA95sVzqM2kBbZMSv9ga8130_assertion evidence source_evidence_literature NP423764.RA8NRfMl3pTf4kFHQeeoZI2RHA95sVzqM2kBbZMSv9ga8130_provenance.
- NP423764.RA8NRfMl3pTf4kFHQeeoZI2RHA95sVzqM2kBbZMSv9ga8130_assertion SIO_000772 21726627 NP423764.RA8NRfMl3pTf4kFHQeeoZI2RHA95sVzqM2kBbZMSv9ga8130_provenance.
- NP423764.RA8NRfMl3pTf4kFHQeeoZI2RHA95sVzqM2kBbZMSv9ga8130_assertion wasDerivedFrom befree-20140225 NP423764.RA8NRfMl3pTf4kFHQeeoZI2RHA95sVzqM2kBbZMSv9ga8130_provenance.
- NP423764.RA8NRfMl3pTf4kFHQeeoZI2RHA95sVzqM2kBbZMSv9ga8130_assertion wasGeneratedBy ECO_0000203 NP423764.RA8NRfMl3pTf4kFHQeeoZI2RHA95sVzqM2kBbZMSv9ga8130_provenance.