Matches in Nanopublications for { <http://rdf.disgenet.org/nanopublications.trig#NP46035.RA5q1X1VsB_brphZLAHDyqSNOSWeH0UftAT6rgkc3a1PA130_assertion> ?p ?o ?g. }
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- NP46035.RA5q1X1VsB_brphZLAHDyqSNOSWeH0UftAT6rgkc3a1PA130_assertion type Assertion NP46035.RA5q1X1VsB_brphZLAHDyqSNOSWeH0UftAT6rgkc3a1PA130_head.
- NP46035.RA5q1X1VsB_brphZLAHDyqSNOSWeH0UftAT6rgkc3a1PA130_assertion description "[No significant correlation was found between the level of 8-OH-dG and the MnSOD, GSTM1, and hOGG1 polymorphisms. However, one novel polymorphism/mutation of the hOGG1 gene was found in a pancreatic tumor. Mutation at codon 12 of the K-ras gene was found in 25 (81%) of 31 pancreatic tumors, including three G-to-A transitions and 22 G-to-T transversions. Patients with the G-to-T mutation had a significantly higher level of aromatic DNA adducts than those with G-to-A or wild-type codon (P=0.02). On the other hand, the K-ras mutation profile was not related to the level of 8-OH-dG. Given the limitation of sample size, these preliminary data lend further support the hypothesis that carcinogen exposure and oxidative stress are involved in pancreatic carcinogenesis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP46035.RA5q1X1VsB_brphZLAHDyqSNOSWeH0UftAT6rgkc3a1PA130_provenance.
- NP46035.RA5q1X1VsB_brphZLAHDyqSNOSWeH0UftAT6rgkc3a1PA130_assertion evidence source_evidence_literature NP46035.RA5q1X1VsB_brphZLAHDyqSNOSWeH0UftAT6rgkc3a1PA130_provenance.
- NP46035.RA5q1X1VsB_brphZLAHDyqSNOSWeH0UftAT6rgkc3a1PA130_assertion SIO_000772 11719088 NP46035.RA5q1X1VsB_brphZLAHDyqSNOSWeH0UftAT6rgkc3a1PA130_provenance.
- NP46035.RA5q1X1VsB_brphZLAHDyqSNOSWeH0UftAT6rgkc3a1PA130_assertion wasDerivedFrom gad-20130706 NP46035.RA5q1X1VsB_brphZLAHDyqSNOSWeH0UftAT6rgkc3a1PA130_provenance.
- NP46035.RA5q1X1VsB_brphZLAHDyqSNOSWeH0UftAT6rgkc3a1PA130_assertion wasGeneratedBy ECO_0000203 NP46035.RA5q1X1VsB_brphZLAHDyqSNOSWeH0UftAT6rgkc3a1PA130_provenance.