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- NP707849.RA7FmQDmcjk9ge5XoHT8hMqCLsMx23PfXD0WT88aYqyjQ130_assertion type Assertion NP707849.RA7FmQDmcjk9ge5XoHT8hMqCLsMx23PfXD0WT88aYqyjQ130_head.
- NP707849.RA7FmQDmcjk9ge5XoHT8hMqCLsMx23PfXD0WT88aYqyjQ130_assertion description "[This approach provided a `metabolic window` to brain characteristics in Mecp2-null mice (n = 4), revealing (i) the first metabolic evidence of astrocyte involvement in RS (decreased levels of the astrocyte marker, myo-inositol, vs. wild-type mice; p = 0.034); (ii) reduced choline phospholipid turnover in Mecp2-null vs. wild-type mice, implying a diminished potential of cells to grow, paralleled by globally reduced brain size and perturbed osmoregulation; (iii) alterations of the platelet activating factor (PAF) cycle in Mecp2-null mouse brains, where PAF is a bioactive lipid acting on neuronal growth, glutamate exocytosis and other processes; and (iv) changes in glutamine/glutamate ratios (p = 0.034) in Mecp2-null mouse brains potentially indicating altered neurotransmitter recycling.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP707849.RA7FmQDmcjk9ge5XoHT8hMqCLsMx23PfXD0WT88aYqyjQ130_provenance.
- NP707849.RA7FmQDmcjk9ge5XoHT8hMqCLsMx23PfXD0WT88aYqyjQ130_assertion evidence source_evidence_literature NP707849.RA7FmQDmcjk9ge5XoHT8hMqCLsMx23PfXD0WT88aYqyjQ130_provenance.
- NP707849.RA7FmQDmcjk9ge5XoHT8hMqCLsMx23PfXD0WT88aYqyjQ130_assertion SIO_000772 17237885 NP707849.RA7FmQDmcjk9ge5XoHT8hMqCLsMx23PfXD0WT88aYqyjQ130_provenance.
- NP707849.RA7FmQDmcjk9ge5XoHT8hMqCLsMx23PfXD0WT88aYqyjQ130_assertion wasDerivedFrom befree-20140225 NP707849.RA7FmQDmcjk9ge5XoHT8hMqCLsMx23PfXD0WT88aYqyjQ130_provenance.
- NP707849.RA7FmQDmcjk9ge5XoHT8hMqCLsMx23PfXD0WT88aYqyjQ130_assertion wasGeneratedBy ECO_0000203 NP707849.RA7FmQDmcjk9ge5XoHT8hMqCLsMx23PfXD0WT88aYqyjQ130_provenance.