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- NP875683.RAP-krTZIES3gPGto8QedgckJC03pZmfLhDVXgwGHAayA130_assertion type Assertion NP875683.RAP-krTZIES3gPGto8QedgckJC03pZmfLhDVXgwGHAayA130_head.
- NP875683.RAP-krTZIES3gPGto8QedgckJC03pZmfLhDVXgwGHAayA130_assertion description "[Key immunopathologic features include: (a) an increased prevalence of particular HLA-DR/DQ alleles; (b) induction of HLA-DR/DQ proteins on the epithelial cells in salivary and lacrimal gland biopsies; (c) infiltration of the glands by CD4+ T-cells that transcribe IL-2 and IFN-gamma; (d) induction of granzyme A and perforin in CD4+ T-cells, suggesting a mechanism of cellular destruction of the glands; (e) clonal expansion of B-cells that use a particular light chain within the salivary gland; (f) production of autoantibodies against nuclear antigens SS-A (60 and 52 kDa) and SS-B (48 kDa), indicating a failure of normal tolerance mechanisms; and (g) increased frequency of B-cell non-Hodgkin's lymphoma.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP875683.RAP-krTZIES3gPGto8QedgckJC03pZmfLhDVXgwGHAayA130_provenance.
- NP875683.RAP-krTZIES3gPGto8QedgckJC03pZmfLhDVXgwGHAayA130_assertion evidence source_evidence_literature NP875683.RAP-krTZIES3gPGto8QedgckJC03pZmfLhDVXgwGHAayA130_provenance.
- NP875683.RAP-krTZIES3gPGto8QedgckJC03pZmfLhDVXgwGHAayA130_assertion SIO_000772 8934921 NP875683.RAP-krTZIES3gPGto8QedgckJC03pZmfLhDVXgwGHAayA130_provenance.
- NP875683.RAP-krTZIES3gPGto8QedgckJC03pZmfLhDVXgwGHAayA130_assertion wasDerivedFrom befree-20140225 NP875683.RAP-krTZIES3gPGto8QedgckJC03pZmfLhDVXgwGHAayA130_provenance.
- NP875683.RAP-krTZIES3gPGto8QedgckJC03pZmfLhDVXgwGHAayA130_assertion wasGeneratedBy ECO_0000203 NP875683.RAP-krTZIES3gPGto8QedgckJC03pZmfLhDVXgwGHAayA130_provenance.