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- NP899433.RAtSueX86BmChyy-W4qq4XC0xgXQUmWmB8hs5qyKqUfqc130_assertion type Assertion NP899433.RAtSueX86BmChyy-W4qq4XC0xgXQUmWmB8hs5qyKqUfqc130_head.
- NP899433.RAtSueX86BmChyy-W4qq4XC0xgXQUmWmB8hs5qyKqUfqc130_assertion description "[There are three presumable mechanisms involved in the development of POI, namely apoptosis acceleration, follicular maturation blocking and premature follicle activation, through the following studied causes: (i) chromosomal abnormalities or gene mutations: mostly involve X chromosome, such as FMR1 premutation; more and more potentially causal genes have been screened recently; (ii) metabolic disorders such as classic galactosaemia and 17-OH deficiency; (iii) autoimmune mediated ovarian damage: observed alone or with some certain autoimmune disorders and syndromes; but the specificity and sensitivity of antibodies towards ovary are still questionable; (iv) iatrogenic: radiotherapy or chemotherapy used in cancer treatment, as well as pelvic surgery with potential threat to ovaries' blood supply can directly damage ovarian function; (v) virus infection such as HIV and mumps; (vi) toxins and other environmental/lifestyle factors: cigarette smoking, toxins (e.g., 4-vinylcyclohexene diepoxide), and other environmental factors are associated with the development of POI.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP899433.RAtSueX86BmChyy-W4qq4XC0xgXQUmWmB8hs5qyKqUfqc130_provenance.
- NP899433.RAtSueX86BmChyy-W4qq4XC0xgXQUmWmB8hs5qyKqUfqc130_assertion evidence source_evidence_literature NP899433.RAtSueX86BmChyy-W4qq4XC0xgXQUmWmB8hs5qyKqUfqc130_provenance.
- NP899433.RAtSueX86BmChyy-W4qq4XC0xgXQUmWmB8hs5qyKqUfqc130_assertion SIO_000772 22932883 NP899433.RAtSueX86BmChyy-W4qq4XC0xgXQUmWmB8hs5qyKqUfqc130_provenance.
- NP899433.RAtSueX86BmChyy-W4qq4XC0xgXQUmWmB8hs5qyKqUfqc130_assertion wasDerivedFrom befree-20140225 NP899433.RAtSueX86BmChyy-W4qq4XC0xgXQUmWmB8hs5qyKqUfqc130_provenance.
- NP899433.RAtSueX86BmChyy-W4qq4XC0xgXQUmWmB8hs5qyKqUfqc130_assertion wasGeneratedBy ECO_0000203 NP899433.RAtSueX86BmChyy-W4qq4XC0xgXQUmWmB8hs5qyKqUfqc130_provenance.