Matches in Nanopublications for { <http://rdf.disgenet.org/resource/nanopub/NP1010720.RA6hS8taeEOfrmDB5jE57JNhq48TAWPapf01KPkhYZSeI130_assertion> ?p ?o ?g. }
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- NP1010720.RA6hS8taeEOfrmDB5jE57JNhq48TAWPapf01KPkhYZSeI130_assertion type Assertion NP1010720.RA6hS8taeEOfrmDB5jE57JNhq48TAWPapf01KPkhYZSeI130_head.
- NP1010720.RA6hS8taeEOfrmDB5jE57JNhq48TAWPapf01KPkhYZSeI130_assertion description "[Systemic monocytes, tissue resident macrophages, dendritic cells and microglia have specific roles in immune surveillance and maintenance of tissue homeostasis and are key regulator and effector cells of the local immune response to acute and chronic tissue injury.Two major signalling pathways that differentially define trafficking behaviour and activation of systemic and local myeloid cell populations in response to exogenous and endogenous inflammatory stimuli are the Ccl2-Ccr2 and the Cx3cl1-Cx3cr1 chemokine pathways.Alterations in these pathways have been implicated in controlling myeloid cell activation during normal ageing and in age-related retinal degenerations, including age-related macular degeneration (AMD).We review the evidence for how altered chemokine signalling in acute and chronic inflammatory conditions regulate local and systemic myeloid cell responses in the retina and how this may contribute to or attenuate pathology in inherited and age-related retinal diseases.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP1010720.RA6hS8taeEOfrmDB5jE57JNhq48TAWPapf01KPkhYZSeI130_provenance.
- NP1010720.RA6hS8taeEOfrmDB5jE57JNhq48TAWPapf01KPkhYZSeI130_assertion evidence source_evidence_literature NP1010720.RA6hS8taeEOfrmDB5jE57JNhq48TAWPapf01KPkhYZSeI130_provenance.
- NP1010720.RA6hS8taeEOfrmDB5jE57JNhq48TAWPapf01KPkhYZSeI130_assertion SIO_000772 24664727 NP1010720.RA6hS8taeEOfrmDB5jE57JNhq48TAWPapf01KPkhYZSeI130_provenance.
- NP1010720.RA6hS8taeEOfrmDB5jE57JNhq48TAWPapf01KPkhYZSeI130_assertion wasDerivedFrom befree-20150227 NP1010720.RA6hS8taeEOfrmDB5jE57JNhq48TAWPapf01KPkhYZSeI130_provenance.
- NP1010720.RA6hS8taeEOfrmDB5jE57JNhq48TAWPapf01KPkhYZSeI130_assertion wasGeneratedBy ECO_0000203 NP1010720.RA6hS8taeEOfrmDB5jE57JNhq48TAWPapf01KPkhYZSeI130_provenance.