Matches in Nanopublications for { <http://rdf.disgenet.org/resource/nanopub/NP1191214.RAb8v5IwkDSAUX5j78D4SB9H0BCugmFOVcw1Zh5VLW4TE130_assertion> ?p ?o ?g. }
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- NP1191214.RAb8v5IwkDSAUX5j78D4SB9H0BCugmFOVcw1Zh5VLW4TE130_assertion type Assertion NP1191214.RAb8v5IwkDSAUX5j78D4SB9H0BCugmFOVcw1Zh5VLW4TE130_head.
- NP1191214.RAb8v5IwkDSAUX5j78D4SB9H0BCugmFOVcw1Zh5VLW4TE130_assertion description "[The most promising include: i) vertical targeting of either MEK or phosphoinositide-3 kinase (PI3K)/mammalian target of rapamycin (mTOR) pathways, or their combined blockade; ii) association of receptor tyrosine kinases (RTKs) inhibitors with other pro-apoptotic strategies; iii) engagement of death receptors in combination with MEK-, mTOR/PI3K-, histone deacetylase (HDAC)-inhibitors, or with anti-apoptotic molecules modulators; iv) strategies aimed at blocking anti-apoptotic proteins belonging to B-cell lymphoma (Bcl-2) or inhibitors of apoptosis (IAP) families associated with MEK/BRAF/p38 inhibition; v) co-inhibition of other molecules important for survival [proteasome, HDAC and Signal transducers and activators of transcription (Stat)3] and the major pathways activated in melanoma; vi) simultaneous targeting of multiple anti-apoptotic molecules.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP1191214.RAb8v5IwkDSAUX5j78D4SB9H0BCugmFOVcw1Zh5VLW4TE130_provenance.
- NP1191214.RAb8v5IwkDSAUX5j78D4SB9H0BCugmFOVcw1Zh5VLW4TE130_assertion evidence source_evidence_literature NP1191214.RAb8v5IwkDSAUX5j78D4SB9H0BCugmFOVcw1Zh5VLW4TE130_provenance.
- NP1191214.RAb8v5IwkDSAUX5j78D4SB9H0BCugmFOVcw1Zh5VLW4TE130_assertion SIO_000772 24920406 NP1191214.RAb8v5IwkDSAUX5j78D4SB9H0BCugmFOVcw1Zh5VLW4TE130_provenance.
- NP1191214.RAb8v5IwkDSAUX5j78D4SB9H0BCugmFOVcw1Zh5VLW4TE130_assertion wasDerivedFrom befree-2016 NP1191214.RAb8v5IwkDSAUX5j78D4SB9H0BCugmFOVcw1Zh5VLW4TE130_provenance.
- NP1191214.RAb8v5IwkDSAUX5j78D4SB9H0BCugmFOVcw1Zh5VLW4TE130_assertion wasGeneratedBy ECO_0000203 NP1191214.RAb8v5IwkDSAUX5j78D4SB9H0BCugmFOVcw1Zh5VLW4TE130_provenance.