Matches in Nanopublications for { <http://rdf.disgenet.org/resource/nanopub/NP408365.RAFsbMS5os03aOfee4W9RKHrrNGXfSVezjkPP3CohJiAk130_assertion> ?p ?o ?g. }
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- NP408365.RAFsbMS5os03aOfee4W9RKHrrNGXfSVezjkPP3CohJiAk130_assertion type Assertion NP408365.RAFsbMS5os03aOfee4W9RKHrrNGXfSVezjkPP3CohJiAk130_head.
- NP408365.RAFsbMS5os03aOfee4W9RKHrrNGXfSVezjkPP3CohJiAk130_assertion description "[This review focuses on three key molecular mechanisms of glucocorticoid resistance in IBD: (i) decreased cytoplasmic glucocorticoid concentration secondary to increased P-glycoprotein-mediated efflux of glucocorticoid from target cells due to overexpression of the multidrug resistance gene (MDR1); (ii) impaired glucocorticoid signaling because of dysfunction at the level of the glucocorticoid receptor; and (iii) constitutive epithelial activation of proinflammatory mediators, including nuclear factor kappa B, resulting in inhibition of glucocorticoid receptor transcriptional activity.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP408365.RAFsbMS5os03aOfee4W9RKHrrNGXfSVezjkPP3CohJiAk130_provenance.
- NP408365.RAFsbMS5os03aOfee4W9RKHrrNGXfSVezjkPP3CohJiAk130_assertion evidence source_evidence_literature NP408365.RAFsbMS5os03aOfee4W9RKHrrNGXfSVezjkPP3CohJiAk130_provenance.
- NP408365.RAFsbMS5os03aOfee4W9RKHrrNGXfSVezjkPP3CohJiAk130_assertion SIO_000772 12967327 NP408365.RAFsbMS5os03aOfee4W9RKHrrNGXfSVezjkPP3CohJiAk130_provenance.
- NP408365.RAFsbMS5os03aOfee4W9RKHrrNGXfSVezjkPP3CohJiAk130_assertion wasDerivedFrom befree-2016 NP408365.RAFsbMS5os03aOfee4W9RKHrrNGXfSVezjkPP3CohJiAk130_provenance.
- NP408365.RAFsbMS5os03aOfee4W9RKHrrNGXfSVezjkPP3CohJiAk130_assertion wasGeneratedBy ECO_0000203 NP408365.RAFsbMS5os03aOfee4W9RKHrrNGXfSVezjkPP3CohJiAk130_provenance.