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- NP471381.RACO4__2YF0W9Oq7j0x1Fr-o3WRjUPNeRoBZdGSl7_OIw130_assertion type Assertion NP471381.RACO4__2YF0W9Oq7j0x1Fr-o3WRjUPNeRoBZdGSl7_OIw130_head.
- NP471381.RACO4__2YF0W9Oq7j0x1Fr-o3WRjUPNeRoBZdGSl7_OIw130_assertion description "[Our major findings were: (1) one or more of the three genes was frequently methylated in L/L and MM cell lines and there was good concordance (90-100%) between methylation and loss of gene expression; (2) treatment of L/L cell lines with a demethylating agent resulted in re-expression of SHP1 protein and downregulation of phosphorylated STAT3 in L/L cell lines; (3) all 55 control specimens and the lymphoblastoid cultures were negative for methylation of the three genes; (4) non-Hodgkin's lymphomas (100%), and leukemias (94%) had almost universal methylation of SHP1 and relatively less frequent (<30%) methylation of SOCS1 and SYK; (5) MM and monoclonal gammopathy of unknown significance (MGUS) had infrequent methylation of SHP1 (<20%), and occasional methylation of SOCS1 and SYK; and (6) comparable methylation frequencies for SOCS1 were observed in MM and MGUS, suggesting that SOCS1 methylation is an early event in MM pathogenesis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP471381.RACO4__2YF0W9Oq7j0x1Fr-o3WRjUPNeRoBZdGSl7_OIw130_provenance.
- NP471381.RACO4__2YF0W9Oq7j0x1Fr-o3WRjUPNeRoBZdGSl7_OIw130_assertion evidence source_evidence_literature NP471381.RACO4__2YF0W9Oq7j0x1Fr-o3WRjUPNeRoBZdGSl7_OIw130_provenance.
- NP471381.RACO4__2YF0W9Oq7j0x1Fr-o3WRjUPNeRoBZdGSl7_OIw130_assertion SIO_000772 15580314 NP471381.RACO4__2YF0W9Oq7j0x1Fr-o3WRjUPNeRoBZdGSl7_OIw130_provenance.
- NP471381.RACO4__2YF0W9Oq7j0x1Fr-o3WRjUPNeRoBZdGSl7_OIw130_assertion wasDerivedFrom befree-2016 NP471381.RACO4__2YF0W9Oq7j0x1Fr-o3WRjUPNeRoBZdGSl7_OIw130_provenance.
- NP471381.RACO4__2YF0W9Oq7j0x1Fr-o3WRjUPNeRoBZdGSl7_OIw130_assertion wasGeneratedBy ECO_0000203 NP471381.RACO4__2YF0W9Oq7j0x1Fr-o3WRjUPNeRoBZdGSl7_OIw130_provenance.