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- NP494394.RAbVMb-j5hH6JQBcGRBql1wiXEJRx-QjY4gjYsjNPaRq0130_assertion type Assertion NP494394.RAbVMb-j5hH6JQBcGRBql1wiXEJRx-QjY4gjYsjNPaRq0130_head.
- NP494394.RAbVMb-j5hH6JQBcGRBql1wiXEJRx-QjY4gjYsjNPaRq0130_assertion description "[Specifically: (1) transgenic expression of the cytokines IL-6, IL-3 and IFN-alpha in the CNS results in the development of acute (high expression) or chronic progressive (low expression) CNS disease associated with a spectrum of clinical, physiologic and pathologic manifestations; (2) although the clinical, cellular and molecular phenotype produced by the cerebral expression of the various cytokines showed some overlap, the differences were more prominent reflecting the unique actions of each cytokine; (3) these transgenic models which recapitulate many of the structural and functional impairments seen in human neurodegenerative diseases, highlight the point that cytokines, which normally function as primary regulators of the host response, also have the potential to mediate significant injury in the CNS.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP494394.RAbVMb-j5hH6JQBcGRBql1wiXEJRx-QjY4gjYsjNPaRq0130_provenance.
- NP494394.RAbVMb-j5hH6JQBcGRBql1wiXEJRx-QjY4gjYsjNPaRq0130_assertion evidence source_evidence_literature NP494394.RAbVMb-j5hH6JQBcGRBql1wiXEJRx-QjY4gjYsjNPaRq0130_provenance.
- NP494394.RAbVMb-j5hH6JQBcGRBql1wiXEJRx-QjY4gjYsjNPaRq0130_assertion SIO_000772 7572281 NP494394.RAbVMb-j5hH6JQBcGRBql1wiXEJRx-QjY4gjYsjNPaRq0130_provenance.
- NP494394.RAbVMb-j5hH6JQBcGRBql1wiXEJRx-QjY4gjYsjNPaRq0130_assertion wasDerivedFrom befree-20150227 NP494394.RAbVMb-j5hH6JQBcGRBql1wiXEJRx-QjY4gjYsjNPaRq0130_provenance.
- NP494394.RAbVMb-j5hH6JQBcGRBql1wiXEJRx-QjY4gjYsjNPaRq0130_assertion wasGeneratedBy ECO_0000203 NP494394.RAbVMb-j5hH6JQBcGRBql1wiXEJRx-QjY4gjYsjNPaRq0130_provenance.