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- NP509975.RAk4irNGvyBnH2iqZGqo5cSGNhTfilOtKS11__XX6vP-0130_assertion type Assertion NP509975.RAk4irNGvyBnH2iqZGqo5cSGNhTfilOtKS11__XX6vP-0130_head.
- NP509975.RAk4irNGvyBnH2iqZGqo5cSGNhTfilOtKS11__XX6vP-0130_assertion description "[Here we showed that (a) CXCL12/CXCR4 axis is expressed in PC bone metastasis; (b) exogenous CXCL12 induced MMP-9 expression by PC cells; (c) bone stromal cells and bone tissue conditioned media induced the migration of PC cells in a CXCR4-dependent manner; (d) pharmacological inhibition of PI3 kinase and MAP kinase pathways abrogated CXCL12-induced MMP-9 expression and invasion of PC cells; (e) exogenous CXCL12 induced Akt1 phosphorylation is indispensable for proMMP-9 secretion, migration, and invasion of PC cells; (f) CXCR4 was localized to lipid rafts in PC cells and initiated Akt phosphorylation.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP509975.RAk4irNGvyBnH2iqZGqo5cSGNhTfilOtKS11__XX6vP-0130_provenance.
- NP509975.RAk4irNGvyBnH2iqZGqo5cSGNhTfilOtKS11__XX6vP-0130_assertion evidence source_evidence_literature NP509975.RAk4irNGvyBnH2iqZGqo5cSGNhTfilOtKS11__XX6vP-0130_provenance.
- NP509975.RAk4irNGvyBnH2iqZGqo5cSGNhTfilOtKS11__XX6vP-0130_assertion SIO_000772 16114056 NP509975.RAk4irNGvyBnH2iqZGqo5cSGNhTfilOtKS11__XX6vP-0130_provenance.
- NP509975.RAk4irNGvyBnH2iqZGqo5cSGNhTfilOtKS11__XX6vP-0130_assertion wasDerivedFrom befree-2016 NP509975.RAk4irNGvyBnH2iqZGqo5cSGNhTfilOtKS11__XX6vP-0130_provenance.
- NP509975.RAk4irNGvyBnH2iqZGqo5cSGNhTfilOtKS11__XX6vP-0130_assertion wasGeneratedBy ECO_0000203 NP509975.RAk4irNGvyBnH2iqZGqo5cSGNhTfilOtKS11__XX6vP-0130_provenance.