Matches in Nanopublications for { <http://rdf.disgenet.org/resource/nanopub/NP567445.RATh2G7gBjxlBvVuxN-f4QrVAtXP7Yl-Pvm0Dz2P7VQPg130_assertion> ?p ?o ?g. }
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- NP567445.RATh2G7gBjxlBvVuxN-f4QrVAtXP7Yl-Pvm0Dz2P7VQPg130_assertion type Assertion NP567445.RATh2G7gBjxlBvVuxN-f4QrVAtXP7Yl-Pvm0Dz2P7VQPg130_head.
- NP567445.RATh2G7gBjxlBvVuxN-f4QrVAtXP7Yl-Pvm0Dz2P7VQPg130_assertion description "[We present evidence, which indicates that (a) MAK physically associates with AR (MAK and AR are found to be coprecipitated from cell extracts, colocalized in nucleus, and corecruited to prostate-specific antigen promoter in LNCaP as well as in transfected cells); (b) MAK is able to enhance AR transactivation potential in an androgen- and kinase-dependent manner in several prostate cancer cells and synergize with ACTR/steroid receptor coactivator-3 coactivator; (c) small hairpin RNA (shRNA) knocks down MAK expression resulting in the reduction of AR transactivation ability; (d) MAK-shRNA or kinase-dead mutant, when introduced into LNCaP cells, reduces the growth of the cells; and (e) microarray analysis of LNCaP cells carrying kinase-dead MAK mutant showed a significant impediment of AR signaling, indicating that endogenous MAK plays a general role in AR function in prostate cancer cells and likely to be a general coactivator of AR in prostate tissues.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP567445.RATh2G7gBjxlBvVuxN-f4QrVAtXP7Yl-Pvm0Dz2P7VQPg130_provenance.
- NP567445.RATh2G7gBjxlBvVuxN-f4QrVAtXP7Yl-Pvm0Dz2P7VQPg130_assertion evidence source_evidence_literature NP567445.RATh2G7gBjxlBvVuxN-f4QrVAtXP7Yl-Pvm0Dz2P7VQPg130_provenance.
- NP567445.RATh2G7gBjxlBvVuxN-f4QrVAtXP7Yl-Pvm0Dz2P7VQPg130_assertion SIO_000772 16951154 NP567445.RATh2G7gBjxlBvVuxN-f4QrVAtXP7Yl-Pvm0Dz2P7VQPg130_provenance.
- NP567445.RATh2G7gBjxlBvVuxN-f4QrVAtXP7Yl-Pvm0Dz2P7VQPg130_assertion wasDerivedFrom befree-2016 NP567445.RATh2G7gBjxlBvVuxN-f4QrVAtXP7Yl-Pvm0Dz2P7VQPg130_provenance.
- NP567445.RATh2G7gBjxlBvVuxN-f4QrVAtXP7Yl-Pvm0Dz2P7VQPg130_assertion wasGeneratedBy ECO_0000203 NP567445.RATh2G7gBjxlBvVuxN-f4QrVAtXP7Yl-Pvm0Dz2P7VQPg130_provenance.