Matches in Nanopublications for { <http://rdf.disgenet.org/resource/nanopub/NP646483.RAfQXHf2kovFZvo63nl8_AQc8I39uXrb6jboD3ZbN-LWs130_assertion> ?p ?o ?g. }
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- NP646483.RAfQXHf2kovFZvo63nl8_AQc8I39uXrb6jboD3ZbN-LWs130_assertion type Assertion NP646483.RAfQXHf2kovFZvo63nl8_AQc8I39uXrb6jboD3ZbN-LWs130_head.
- NP646483.RAfQXHf2kovFZvo63nl8_AQc8I39uXrb6jboD3ZbN-LWs130_assertion description "[pVHL, VHL gene product and a protein member of the E3 ubiquitin ligase family, acts in normal cells to direct the degradation and clearance of the hypoxia inducible factor (HIF)alpha transcription factor family, such that in its absence, as in ccRCC, the HIF proteins stabilize, accumulate to supraphysiologic levels and activate the transcription of genes such as VEGF and PDGF, which contributes substantially to the physiology of the tumor, and has been assessed indirectly as a prognostic factor.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP646483.RAfQXHf2kovFZvo63nl8_AQc8I39uXrb6jboD3ZbN-LWs130_provenance.
- NP646483.RAfQXHf2kovFZvo63nl8_AQc8I39uXrb6jboD3ZbN-LWs130_assertion evidence source_evidence_literature NP646483.RAfQXHf2kovFZvo63nl8_AQc8I39uXrb6jboD3ZbN-LWs130_provenance.
- NP646483.RAfQXHf2kovFZvo63nl8_AQc8I39uXrb6jboD3ZbN-LWs130_assertion SIO_000772 18095884 NP646483.RAfQXHf2kovFZvo63nl8_AQc8I39uXrb6jboD3ZbN-LWs130_provenance.
- NP646483.RAfQXHf2kovFZvo63nl8_AQc8I39uXrb6jboD3ZbN-LWs130_assertion wasDerivedFrom befree-2016 NP646483.RAfQXHf2kovFZvo63nl8_AQc8I39uXrb6jboD3ZbN-LWs130_provenance.
- NP646483.RAfQXHf2kovFZvo63nl8_AQc8I39uXrb6jboD3ZbN-LWs130_assertion wasGeneratedBy ECO_0000203 NP646483.RAfQXHf2kovFZvo63nl8_AQc8I39uXrb6jboD3ZbN-LWs130_provenance.