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- NP698381.RAZHQW2F-mcJ7_1TIxeEH9paY7xNZL9yt62O6mw8WhEx0130_assertion type Assertion NP698381.RAZHQW2F-mcJ7_1TIxeEH9paY7xNZL9yt62O6mw8WhEx0130_head.
- NP698381.RAZHQW2F-mcJ7_1TIxeEH9paY7xNZL9yt62O6mw8WhEx0130_assertion description "[This model is consistent with all of the present knowledge about ADHD including (a) the increased frequency of ADHD in the relatives of ADHD probands, (b) the presence of a wide spectrum of comorbid behaviors (depression, anxiety, learning, conduct, oppositional-defiant, conduct and substance abuse disorders) in ADHD probands and their relatives on both parental sides, (c) the close relationship to Tourette syndrome (TS), (d) the failure to find the genes for TS using linkage analysis, (e) the brain imaging studies showing hypometabolism of the frontal lobes, (f) the relationship between dopamine D2 receptor density and regional blood flow, (g) the correlation between tics and dopamine D2 receptor density in TS, (h) the motor hyperactivity of dopamine transporter and dopamine D3 receptor gene knockout mice, (i) the LeMoal and Shaywitz dopamine deficiency animal models of ADHD, (j) the NE models of ADHD, (k) the failure to explain ADHD on the basis of any single neurotransmitter defect, (l) the response of ADHD to dopamine and alpha 2-adrenergic agonists, (m) the small percentage of the variance of specific behaviors accounted for by each gene, and numerous other aspects of ADHD.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP698381.RAZHQW2F-mcJ7_1TIxeEH9paY7xNZL9yt62O6mw8WhEx0130_provenance.
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