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- _10 value "Our results show that VEGF induces the association of CADTK with the b1 integrin/PKCa protein complex...VEGFR immunoprecipitation and immunoblotting studies using anti-Flt-1 and anti-CADTK Abs showed specific constitutive association...VEGF increased (2-fold) fibronectin-induced CADTK tyrosine phosphorylation in MM.1S cells; equivalent loading of proteins was confirmed by stripping and reprobing the membrane with anti-CADTK Ab. The PKC activator PMA enhanced constitutive phosphorylation of CADTK (Fig. 4c). Finally, VEGF-triggered CADTK activation was blocked by both the PKC inhibitor BIM I and a b1 integrin neutralizing mAb...These results indicate that the activation of CADTK in adherent MM cells is influenced by both PKC- and b1 integrin-mediated signaling pathways." provenance.
- _10 wasQuotedFrom 11751905 provenance.