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- _5 value "To investigate whether JNK/AP1 dependency is a general process common to other SCC cell types, we expressed DNc-Jun in spontaneous human SCC cell lines, A431 and SCC25, and found that DNc-Jun significantly inhibited their s.c. tumor growth as well (Fig. 2B?C). Furthermore, retroviral-mediated RNA interference knockdown of MKK7, the upstream activator of JNK, also prevented s.c. tumor growth of A431, SCC25, and primary keratinocytes transformed by Ras and I?B? (Fig. 2B?D)." provenance.
- _5 wasQuotedFrom 17440097 provenance.