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- _7 value "In a second hydroxylation-dependent control, ?-hydroxylation of an asparaginyl residue in the C-terminal activation domain of HIF-? (Asn803 in human HIF-1?)35 is regulated by a HIF asparaginyl hydroxylase33,36 termed FIH (factor inhibiting HIF)37. Hydroxylation at this site blocks interaction of the HIF-? C-terminal activation domain with the transcriptional coactivator p300." provenance.
- _7 wasQuotedFrom 12778166 provenance.