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- _4 value "We demonstrate that p90rsk-1, p90rsk-2, gsk-3, ERK-2, and p70S6K kinases are components of the protein translation complex. gsk-3b is a constitutively active kinase and phosphorylation by p90rsk inhibits its kinase activity (47). One of the known gsk-3 substrates is the translation initiation factor eIF2B. Phosphorylation of this translation initiation factor decreases translation (49, 50). Thus, inhibition of gsk-3b by p90rsk phosphorylation would result in a rapid increase in translation. " provenance.
- _4 wasQuotedFrom 9844018 provenance.