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- _4 value "Mutations in hepatocyte nuclear factor 1 alpha (HNF-1A) lead to maturity-onset diabetes of the young type 3 as a result of impaired insulin secretory response in pancreatic Beta-cells. Furthermore the expression of steady-state mRNA levels of gene encoding neutral and neutral and basic amino acid transporter (Nbat) was found to be decreased in Hnf-1-/- mice. In the liver of Hnf-1-/- mice, mRNA levels of Nbat was also reduced by 2.2-fold compared with wild-type littermates, suggesting that HNF-1 alpha leads to the expression of Nbat in pancreatic islets and liver of mice." provenance.
- _4 wasQuotedFrom 11679424 provenance.