Matches in Nanopublications for { <http://www.tkuhn.ch/bel2nanopub/RA-tEe-2K3y5Ox22yGxs-L1UFmQntati-vB9jpsUll-eg#_7> ?p ?o ?g. }
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- _7 value "Here we report the discovery of a new functional link between TGF-beta and growth factor signalling pathways, mediated by a physical interaction between the serine-threonine kinase PKB (protein kinase B)/Akt and the transcriptional activator Smad3. Formation of the complex is induced by insulin, but inhibited by TGF-beta stimulation, placing PKB-Smad3 at a point of convergence between these two pathways. Inhibition of Smad3 by PKB occurs through a kinase-activity-independent mechanism, resulting in a decrease in Smad3-mediated transcription and protection of cells against TGF-beta-induced apoptosis." provenance.
- _7 wasQuotedFrom 15048128 provenance.