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- _7 value "Both RhoGDI and D4GDI (hereafter referred to collectively as GDIs) are cytosolic and form 1:1 complexes with Rho family GTPases, although several Rho family members have been reported to not effectively bind to GDIs (Table 1). First, they inhibit the dissociation of GDP from Rho proteins, maintaining the GTPase in an inactive form and preventing GTPase activation by GEFs (Box 1). Second, they are able to interact with the GTP-bound form of the Rho GTPase to inhibit GTP hydrolysis, blocking both intrinsic and GAP-catalyzed GTPase activity and preventing interactions with effector targets." provenance.
- _7 wasQuotedFrom 15921909 provenance.