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- _4 value "PKD induces activation of MAP kinases, MEK4 and MEK3, 6 activities, which are upstream activators of JNK and p38, respectively. BMP-2 also induced the activation of these MEKs and this effect was blunted in AS-PKD (PKD1 antisense mRNA) compared with empty vector-transfected cells suggesting that PKD is probably influencing either the regulation or the activity of a MEK kinase. Thus, BMP2 activated p38 MAPk via PKD through MEK3/6." provenance.
- _4 wasQuotedFrom 14573624 provenance.