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- _7 value "Further, LPS + IFN? -induced expression of iNOS and Nox1 was attenuated by the mitogen-activated protein kinase kinase 1/2 (MEK1/2) inhibitor PD98059, the JNK inhibitor SP600125, the Jak2 inhibitor AG490 and the NF?B inhibitor MG132, but not by the p38 mitogen-activated protein kinase inhibitor SB203580. LPS + IFN? stimulated phosphorylation of ERK, JNK and Jak2, and degradation of I?B, but only Jak2 phosphorylation was sensitive to tripterine (50-200 nM). Further, tripterine diminished the increased vascular permeability in inflamed air pouches." provenance.
- _7 wasQuotedFrom 19508391 provenance.