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- _5 value "Finally, PP1 had no effect on IGF-I-stimulated IRS-1 tyrosine phosphorylation or coimmunoprecipitated p85 subunit of PI3K (Fig. 3)Citation . The differential effects by PP1 on these two substrates of the IGF-I receptor suggest that the Shc/MAPK and IRS-1/PI3K pathways are distinct cascades, and that Shc, but not IRS-1, is a substrate of the SFKs." provenance.
- _5 wasQuotedFrom 11457735 provenance.