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- _4 value "Several reports have demonstrated that the inactivation of pVHL tumour suppressor function is linked to abnormal extracellular fibronectin arrays in both RCC cells that lack functional pVHL and VHLK-K mouse fibroblasts [44 to 46]. However, the exact nature of such an association and the mechanism by which VHL regulates the assembly of this ECM remain poorly understood. Nevertheless, the restored ability of pVHL-positive transfectants to assemble extracellular fibronectin was mediated by b1 integrins, implying that pVHL controls ECM assembly, at least in part, through integrin signalling [46]." provenance.
- _4 wasQuotedFrom 15350900 provenance.