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- _6 value "Inhibition of the RhoA/ROK pathway is perhaps the most important mechanism of Ca2 desensitization by cGMP, as first shown by the dramatic reversal of GTPS (and agonist)-induced Ca2 sensitization of force and RLC phosphorylation in smooth muscle (176, 429) and recently by the effect of upstream stimulation of PKG by NO (65). (65). Chitaley K and Webb RC. Nitric oxide induces dilation of rat aorta via inhibition of rho-kinase signaling. Hypertension 39: 438- 442, 2002." provenance.
- _6 wasQuotedFrom 14506307 provenance.