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- _3 value "Treatment of VSMCs with AG-II was observed to induce premature cellular senescence (overexpression of p53/p21) and increase the production of proinflammatory cytokines through nuclear factor-B activation; both effects were neutralized by blocking the p21 pathway.97 The same effects of AG-II were also observed in vivo in a mouse model of atherosclerosis.97" provenance.
- _3 wasQuotedFrom 18155543 provenance.