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- _3 value "DNA methylation represses transcription in vivo Sp1-like elements have a key role in protecting the CpG island of Aprt (encoding adenine phosphoribosyltransferase) from de novo methylation, and when these elements are specifically mutated, the Aprt CpG island becomes methylated in transgenic mice." provenance.
- _3 wasQuotedFrom 10369268 provenance.