Matches in Nanopublications for { <http://www.tkuhn.ch/bel2nanopub/RA1X9ppBzzeCpEtmf3nWezmeUltrTQZ1T_CPdFTJn6myc#_6> ?p ?o ?g. }
Showing items 1 to 2 of
2
with 100 items per page.
- _6 value "All effects of% histamine on cytokine responses were also abolished by the presence of either anti-IL-18 Ab or IL-1beta-converting enzyme/caspase-1 inhibitor, indicating that the histamine action is dependent on mature IL-18 secretion and that IL-18 production is located upstream of the cytokine cascade activated by histamine. Histamine (10-7 to 10-4 M) concentration-dependently stimulated the production of IL-18 and IFN-gamma and inhibited the production of IL-2 and IL-10 in human PBMCs. The stimulatory or inhibitory effects of histamine on cytokine production were all antagonized by H2 receptor antagonists ranitidine and famotidine in a concentration-dependent manner, but not by H1 and H3 receptor antagonists. The addition of recombinant human IL-18 to the culture concentration-dependently stimulated IL-12 and IFN-gamma production and inhibited the IL-2 and IL-10 production." provenance.
- _6 wasQuotedFrom 10843724 provenance.