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- _5 value "<E22> Raf1 can bind pRb and p130, which are not thereby dissociated from E2F complexes, although promoter inhibition is reversed (Wang et al., 1998). There was no detectable binding to p107. Binding to pRb is mediated by the Nterminal 28 amino acids of Raf1. The kinase activity of Raf1 was required to reverse the pRb-mediated promoter repression (Wang et al., 1998), but the phosphorylation sites on pRb remain to be described and therefore are not indicated in the diagram." provenance.
- _5 wasQuotedFrom 10436023 provenance.