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- _4 value "Importantly, it has been demonstrated that hypoxia promotes tumour cell invasion by inducing the expression of the Met receptor [54]. This establishes a mechanism whereby transformed cells can be spurred to exit a hypoxic microenvironment and invade the surrounding tissues, which provide more favourable growth conditions. Because HIF-1a is involved in Met gene expression, the constitutive activation of HIF-1a as a consequence of pVHL deregulation provides a mechanism explaining the observation that the expression of HGF and Met receptor is associated with genetic alterations of VHL in primary RCC." provenance.
- _4 wasQuotedFrom 15350900 provenance.