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- _5 value "GST-fused PDE5 R domain was phosphorylated by PKA primarily at Ser102. Phosphorylation of the R domain increases affinity for cGMP approximately 10-fold (K(D) values 97.8 +/- 17 and 10.0 +/- 0.5 nm for unphospho- and phospho-R domains, respectively). Increased cGMP binding leads to increased hydrolysis by PDE." provenance.
- _5 wasQuotedFrom 12359732 provenance.