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- _8 value "In vivo, endogenous FAP68 can be coimmunoprecipitated with the HGF receptor in the absence of stimuli and not upon HGF stimulation. Thus, FAP68 represents a novel type of effector that interacts with the inactive HGF receptor and is released upon receptor phosphorylation. # Ariadne: Significantly, nonphosphorylated HGF receptor prevents FAP68 from stimulating p70S6K . [Regulation] # Ariadne: FAP68 interacts specifically with the inactive form of HGF receptor, such as a kinase- defective receptor or a dephosphorylated wild type receptor. [Binding] # Ariadne: Significantly, nonphosphorylated HGF receptor prevents FAP68 from stimulating p70S6K . [Regulation]" provenance.
- _8 wasQuotedFrom 11571281 provenance.