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- _5 value "The activation of TLR2 by Pam3CSK4 induced the degradation of the NF-kB inhibitor IkBa in human monocyte-derived macrophages. NF-kB activation was blocked by S1P at low micromolar concentrations. Statistically significant inhibition of TLR2-dependent NF-kB activation was observed with 1 mM S1P, which argues in favour of a receptor-dependent and physiologically relevant effect (Figure 4A)." provenance.
- _5 wasQuotedFrom 18411230 provenance.