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- _4 value "Functional and biochemical anlaysis of the E-R3 chimera also identified the contribution of tyrosines 1230/1231 to VEGFR-3- dependent proliferation, migration and survival. Our data show that these tyrosine residues activate the classic PI3K/AKT and ERK pathways upon GRB2 direct recruitment to the receptor. This site must collaborate with Y1337, which was previously shown to recruit SHC and indirectly GRB2. " provenance.
- _4 wasQuotedFrom 16076871 provenance.