Matches in Nanopublications for { <http://www.tkuhn.ch/bel2nanopub/RA2kwXio_a7pMnd3rNG8ApmmrWKaxczCchia_rliCnmlY#_6> ?p ?o ?g. }
Showing items 1 to 2 of
2
with 100 items per page.
- _6 value "MUC5AC mucin was measured in cell lysates (filled columns) and in cell supernatants (open columns) by ELISA in confluent cultures of human airway (NCI-H292) epithelial cells incubated for 24 h with medium alone (?TGF-alpha; control), medium alone + 5 ?g/ml of ICAM-1 neutralizing antibody (Ab) (which prevents ligand binding to the first extracellular domain of ICAM-1), or with added TGF-alpha (5 ng/ml; +TGF-alpha) + increasing concentrations of an ICAM-1 neutralizing antibody or + an isotype-matched control antibody (IgG1; 5 ?g/ml). The EGFR ligand TGF-alpha (5 ng/ml, 24 h) increased mucin production 3.5-fold in human airway (NCI-H292) epithelial cells (Fig. 1A). An ICAM-1 neutralizing antibody that prevents ICAM-1 ligand binding to the first extracellular domain of ICAM-1 decreased TGF-alpha-induced mucin production dose-dependently by 60% (Fig. 1A)." provenance.
- _6 wasQuotedFrom 19429776 provenance.