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- _7 value "(From full text) In another approach to indirectly activate endogenous E2F, we employed mutant SAOS2 cells expressing temperature-sensitive pRB [47]. Shift of the culture to permissive temperature, allows the formation of pRB-E2F1 complexes, which would prevent the function of E2F resulting in the derepression of the PAI-1 gene. Accordingly, we found that shift of the culture to the permissive temperature induced PAI-1 mRNA (Fig. 3)Go. In contrast, the temperature shift had no effect on PAI-1 gene expression in control SAOS-2 cells." provenance.
- _7 wasQuotedFrom 11559366 provenance.