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- _4 value "The vascular endothelial growth factor (Vegf) is known to be expressed in labyrinthine trophoblasts of 12.5 day old placentas (Dumont et al., 1995) and to be required for normal vasculogenesis throughout both the embryo and extraembryonic tissues; heterozygotes carrying a null mutation in the gene die during early embryogenesis due to a general failure of vasculogenesis (Carmeliet et al., 1996; Ferrara et al., 1996). Vegf is expressed at a fairly low level in labyrinthine trophoblasts of 10.5 day old placentas and at a much higher level in giant cells at the other pole of the embryo as well as in the embryo itself (Fig. 7C, Dumont et al., 1995 and data not shown). No Vegf expression was detected in the labyrinth of 10.5 dpc TfebFcr homozygous placentas, whereas the giant cells still express the gene (Fig. 7D)." provenance.
- _4 wasQuotedFrom 9806910 provenance.