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- _4 value "Although TBRI, TBRII, Smad2, Smad3, and Smad4 comprise the core Smad-dependent TGF-B signaling pathway, Smad-independent signaling through mitogenactivated protein kinase (MAPK) signaling pathways,20-22 Rho guanosine triphosphatases,23 PI-3 kinase/Akt,24 and protein phosphatase 2A25 has been reported; precise molecular mechanisms by which the TGF-B signaling pathway signals to these pathways have not been established. ROLE OF TGF-B IN THE HALLMARKS OF CANCER BIOLOGY Resistance" provenance.
- _4 wasQuotedFrom 15774796 provenance.