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- _5 value "The reporter MCK4800-luc contains the 4,800-bp upstream region from the MCK gene (19) and has been shown to be transactivated by myogenic bHLH proteins, which bind two adjacent E-boxes in an upstream enhancer (17, 18, 26). MyoD potently activated this reporter gene, and activation was augmented in the presence of exogenous E12 (Fig. 5A). In contrast, MyoR showed no transcriptional activity on its own or with E12 and it completely prevented activation of the reporter gene by MyoD." provenance.
- _5 wasQuotedFrom 9892671 provenance.