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- _5 value "...and is required foreffective cell-type-specific proliferation by directly activating specificgrowth-regulating genes. Regulated exchange of HDAC1/beta-catenin converts Pitx2from repressor to activator, analogous to control of TCF/LEF1. Pitx2 then servesas a competence factor required for the temporally ordered and growthfactor-dependent recruitment of a series of specific coactivator complexes thatprove necessary for Cyclin D2 gene induction." provenance.
- _5 wasQuotedFrom 12464179 provenance.