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- _4 value "Treatment with insulin induced the phosphorylation of IRS-1 and 2 but was inhibited by overexpression of SOCS-1 and 3. But treatment with antisense AS3 and AS1 (Anti-SOCS-3 and 1) or AS3+AS1 in combination restored the phosphorylation of IRS proteins and a modest improvement in PI3-kinase and Akt activity, indicating that overexpression of SOCS-1 and 3 inhibits the insulin induced signaling and led to insulin resistance." provenance.
- _4 wasQuotedFrom 15240880 provenance.