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- _5 value "The connection between TOR and PI3K is revealed by the observation that Akt, which is activated by the PI3K pathway, phosphorylates and inhibits TSC2 (19?21). Furthermore, the understanding of the molecular function of TSC1/2 in regulating TORC1 was significantly advanced when Ras homology enriched in brain (Rheb) was identified as a key component acting downstream of TSC1/2 and upstream of TOR (22?27)... Therefore, a signaling pathway of PI3K-Akt-TSC2-Rheb-TORC1 has been proposed. (from full text)" provenance.
- _5 wasQuotedFrom 16627617 provenance.