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- _6 value "HCPTPA overexpression inhibits VEGFinduced VEGFR2 autophosphorylation, EC migration, and proliferation (46). High cell density-enhanced PTP1 (DEP- 1)/CD148 attenuates phosphorylation of VEGFR2 in contact-inhibited confluent ECs (40). A small molecule inhibitor of PTP1B enhances VEGF-induced VEGFR2 autophosphoryla- tion, migration, and proliferation of EC, as well as neovascularization in a mouse matrigel model (92). Angiopoietin-1 stimulates association of SHP-2 to the phosphorylated Tie-2 receptor (47), which in turn inhibits PI3 kinase-dependent signaling pathways leading to EC migration." provenance.
- _6 wasQuotedFrom 17511588 provenance.