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- _2 value "It is well known that addition of H2O2 can cause oxidative stress and cell death since it easily permeates through the membranes. For the same reason, H2O2 added to a cell culture is quickly decomposed due to activity of catalase and other cellular H2O2-consuming systems. For example, we found that 20 ?M H2O2 added to a culture of HeLa cells was completely decomposed in 15?20 min [19]. On the other hand, significant accumulation of ROS in the H2O2-treated cells was detected 45 min after addition of peroxide (Fig. 7), indicating activation of endogenous ROS production by added H2O2. " provenance.
- _2 wasQuotedFrom 16678116 provenance.