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- _5 value "TNF-{alpha} reduces insulin-stimulated receptor tyrosine kinase activity at low concentrations and can also decrease the expression of the insulin receptor, IRS-1 and GLUT-4 at higher concentrations (22) as well as increase the phosphorylation of serine 307 of IRS-1, thus impairing its ability to bind to the insulin receptor and initiate downstream signaling." provenance.
- _5 wasQuotedFrom 12952969 provenance.