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- _5 value "To determine whether silencing T-bet in vivo also resulted in down-regulation of the IL-23R, whole-cell lysates were prepared directly ex vivo from the splenocytes of EAE-affected mice that had been treated with siRNA-NS or siRNA-T-bet. Western blot analysis demonstrated a 45% reduction in IL-23R at day 18, and IL-23R was undetectable by day 44 in the siRNA-T-bet mice (Fig. 3b)" provenance.
- _5 wasQuotedFrom 17237380 provenance.